Type II Transmembrane Serine Proteases
نویسندگان
چکیده
منابع مشابه
Enteropeptidase, a type II transmembrane serine protease.
Enteropeptidase, a type II transmembrane serine protease, is localized to the brush border of the duodenal and jejunal mucosa. It is synthesized as a zymogen (proenteropeptidase) that requires activation by another protease, either trypsin or possibly duodenase. Active enteropeptidase then converts the pancreatic precursor, trypsinogen, to trypsin by cleavage of the specific trypsinogen activat...
متن کاملType II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymes.
Cell surface proteolysis has emerged as an important mechanism for the generation of biologically active proteins that mediate a diverse range of cellular functions. The proteolytic activities of membrane-anchored proteins, such as ADAMs (1) and MT-MMPs (2), are thought to play central roles in cell surface-activating events. In contrast, most of the members of the serine protease family, one o...
متن کاملType II transmembrane serine protease (TTSP) deregulation in cancer.
The Type II transmembrane serine proteases (TTSP) are a relatively newly identified family of proteolytic enzymes that have become the subject of intense scrutiny in the field of cancer research. Advances in genome screening technology have enabled the identification of putative members and the further characterization of existing members. The TTSPs are involved in a diverse range of physiologi...
متن کاملCleavage Specificity Analysis of Six Type II Transmembrane Serine Proteases (TTSPs) Using PICS with Proteome-Derived Peptide Libraries
BACKGROUND Type II transmembrane serine proteases (TTSPs) are a family of cell membrane tethered serine proteases with unclear roles as their cleavage site specificities and substrate degradomes have not been fully elucidated. Indeed just 52 cleavage sites are annotated in MEROPS, the database of proteases, their substrates and inhibitors. METHODOLOGY/PRINCIPAL FINDING To profile the active s...
متن کاملTMPRSS3, a type II transmembrane serine protease mutated in non-syndromic autosomal recessive deafness.
Recently, we and others have shown that mutations in TMPRSS3 were responsible for autosomal recessive non-syndromic hearing loss. TMPRSS3 is a member of the Type II Transmembrane Serine Protease (TTSP) family and encodes for a protease that also contains LDLRA (low-density lipoprotein receptor class A) and SRCR (scavenger receptor cysteine rich) domains. Fourteen pathogenic mutations, which occ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2009
ISSN: 0021-9258
DOI: 10.1074/jbc.r109.021006